Transcription factors with Perturb-seq knockdown data for NDUFV2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFV2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFV2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:8,937,255–8,938,296 | 198.9 kb | Distal (>10kb) Multiome | 208 | |
| chr18:9,102,098–9,103,261 | 34.0 kb | Distal (>10kb) Multiome | 815 | |
| chr18:9,135,781–9,137,908 | 744 bp | At TSS Multiome | 1018 | |
| chr18:9,264,819–9,265,280 | 128.4 kb | Distal (>10kb) Multiome | 49 | |
| chr18:9,333,728–9,335,352 | 198.0 kb | Distal (>10kb) Multiome | 738 |
Genomic view of the NDUFV2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.