NDUFS7
NADH:ubiquinone oxidoreductase core subunit S7 | CI-20, FLJ45860, FLJ46880, PSST

This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]

Member of: DE-1
Biological processes 30 terms
4 iron, 4 sulfur cluster binding (GO:0051539)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase activity (GO:0003954)aerobic respiration (GO:0009060)aerobic respiration (GO:0009060)electron transport coupled proton transport (GO:0015990)iron-sulfur cluster binding (GO:0051536)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial respiratory chain complex I assembly (GO:0032981)mitochondrial respiratory chain complex I assembly (GO:0032981)mitochondrion (GO:0005739)neuronal cell body (GO:0043025)oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)protease binding (GO:0002020)protein binding (GO:0005515)proton motive force-driven mitochondrial ATP synthesis (GO:0042776)quinone binding (GO:0048038)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)synaptic membrane (GO:0097060)
Expression (TPM)
NDUFS7 — as a Regulated Gene

TFs regulating NDUFS7 0 TFs

Transcription factors with Perturb-seq knockdown data for NDUFS7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFS7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NDUFS7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFS7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:1,094,985–1,095,654 288.4 kb Distal (>10kb) Multiome 671
chr19:1,103,487–1,105,654 279.9 kb Distal (>10kb) Multiome 849
chr19:1,112,029–1,112,884 271.6 kb Distal (>10kb) Multiome 294
chr19:1,113,014–1,114,139 270.3 kb Distal (>10kb) Multiome 690
chr19:1,122,934–1,123,720 260.7 kb Distal (>10kb) Multiome 231
chr19:1,173,441–1,174,438 209.7 kb Distal (>10kb) Multiome 682
chr19:1,194,370–1,194,985 189.3 kb Distal (>10kb) Multiome 531
chr19:1,205,175–1,206,374 178.3 kb Distal (>10kb) Multiome 746
chr19:1,237,080–1,238,434 145.8 kb Distal (>10kb) Multiome 430
chr19:1,239,513–1,242,539 142.2 kb Distal (>10kb) Multiome 889
chr19:1,244,253–1,244,857 139.3 kb Distal (>10kb) Multiome 590
chr19:1,247,981–1,252,501 132.8 kb Distal (>10kb) Multiome 1136
chr19:1,259,185–1,262,955 124.5 kb Distal (>10kb) Multiome 1070
chr19:1,265,280–1,270,235 114.6 kb Distal (>10kb) Multiome 1171
chr19:1,274,423–1,276,502 108.2 kb Distal (>10kb) Multiome HiCAR 967
chr19:1,285,317–1,286,108 98.1 kb Distal (>10kb) Multiome HiCAR 277
chr19:1,354,303–1,355,411 29.0 kb Distal (>10kb) Multiome 688
chr19:1,383,122–1,384,333 243 bp At TSS Multiome 1228
chr19:1,401,101–1,401,839 17.6 kb Distal (>10kb) Multiome 540
chr19:1,406,589–1,408,783 23.5 kb Distal (>10kb) Multiome 911
chr19:1,415,008–1,415,721 31.6 kb Distal (>10kb) Multiome 597
chr19:1,437,988–1,438,998 54.5 kb Distal (>10kb) Multiome 1076
chr19:1,444,785–1,447,383 61.3 kb Distal (>10kb) Multiome 797
chr19:1,455,191–1,456,421 71.9 kb Distal (>10kb) Multiome 491
chr19:1,468,941–1,469,903 85.4 kb Distal (>10kb) Multiome 242
chr19:1,470,088–1,471,597 86.9 kb Distal (>10kb) Multiome 544
chr19:1,478,772–1,479,848 95.4 kb Distal (>10kb) Multiome 857
chr19:1,489,566–1,491,829 107.0 kb Distal (>10kb) Multiome 836
chr19:1,507,230–1,508,699 124.2 kb Distal (>10kb) Multiome 596
chr19:1,512,960–1,513,686 129.3 kb Distal (>10kb) Multiome 541
chr19:1,523,798–1,524,624 140.2 kb Distal (>10kb) Multiome 263
chr19:1,566,277–1,568,916 182.8 kb Distal (>10kb) Multiome 748
chr19:1,592,085–1,593,444 208.8 kb Distal (>10kb) Multiome 883
chr19:1,604,859–1,606,501 221.7 kb Distal (>10kb) Multiome 902
chr19:1,651,519–1,653,514 269.0 kb Distal (>10kb) Multiome 909

Genome Browser

Genomic view of the NDUFS7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:1,084,985 – 1,663,514
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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