The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for NDUFC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:139,014,635–139,016,468 | 286.8 kb | Distal (>10kb) Multiome | 975 | |
| chr4:139,020,400–139,021,056 | 281.8 kb | Distal (>10kb) Multiome | 167 | |
| chr4:139,082,831–139,084,775 | 219.4 kb | Distal (>10kb) Multiome | 1056 | |
| chr4:139,159,062–139,160,313 | 142.7 kb | Distal (>10kb) Multiome | 133 | |
| chr4:139,176,009–139,179,224 | 124.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr4:139,279,361–139,280,628 | 22.3 kb | Distal (>10kb) Multiome | 287 | |
| chr4:139,295,267–139,296,002 | 6.7 kb | Proximal (<10kb) Multiome | 947 | |
| chr4:139,300,735–139,302,627 | 1.1 kb | Proximal (<10kb) Multiome | 912 | |
| chr4:139,453,063–139,454,584 | 151.4 kb | Distal (>10kb) Multiome | 989 | |
| chr4:139,555,161–139,557,952 | 252.9 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the NDUFC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.