Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency 35. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NDUFB10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFB10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFB10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,677,899–1,679,024 | 281.3 kb | Distal (>10kb) Multiome | 709 | |
| chr16:1,705,380–1,706,702 | 253.4 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,763,511–1,764,353 | 195.5 kb | Distal (>10kb) Multiome | 261 | |
| chr16:1,770,847–1,771,973 | 188.0 kb | Distal (>10kb) Multiome | 485 | |
| chr16:1,772,565–1,774,049 | 186.1 kb | Distal (>10kb) Multiome | 956 | |
| chr16:1,781,749–1,783,420 | 176.8 kb | Distal (>10kb) Multiome | 761 | |
| chr16:1,826,102–1,827,535 | 132.6 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:1,918,171–1,918,773 | 41.1 kb | Distal (>10kb) Multiome | 129 | |
| chr16:1,929,283–1,930,271 | 29.7 kb | Distal (>10kb) Multiome | 780 | |
| chr16:1,942,671–1,943,761 | 16.2 kb | Distal (>10kb) Multiome | 750 | |
| chr16:1,958,923–1,960,140 | 52 bp | At TSS Multiome | 826 | |
| chr16:1,960,726–1,961,992 | 1.2 kb | Proximal (<10kb) | 649 | |
| chr16:1,964,300–1,965,434 | 5.4 kb | Proximal (<10kb) Multiome | 933 | |
| chr16:1,971,481–1,972,435 | 12.4 kb | Distal (>10kb) Multiome | 1010 | |
| chr16:1,979,111–1,980,324 | 19.9 kb | Distal (>10kb) Multiome | 296 | |
| chr16:1,983,450–1,984,851 | 24.4 kb | Distal (>10kb) Multiome | 917 | |
| chr16:1,989,307–1,993,568 | 32.8 kb | Distal (>10kb) Multiome | 706 | |
| chr16:2,003,882–2,004,348 | 44.5 kb | Distal (>10kb) Multiome | 619 | |
| chr16:2,009,742–2,010,504 | 50.3 kb | Distal (>10kb) Multiome | 752 | |
| chr16:2,022,700–2,023,923 | 63.7 kb | Distal (>10kb) Multiome | 682 | |
| chr16:2,026,629–2,027,149 | 67.3 kb | Distal (>10kb) Multiome | 249 | |
| chr16:2,047,366–2,048,252 | 88.3 kb | Distal (>10kb) Multiome | 875 | |
| chr16:2,090,476–2,092,232 | 131.8 kb | Distal (>10kb) Multiome | 344 | |
| chr16:2,135,536–2,136,505 | 176.6 kb | Distal (>10kb) Multiome | 263 | |
| chr16:2,147,864–2,149,260 | 189.0 kb | Distal (>10kb) Multiome | 679 | |
| chr16:2,149,550–2,152,180 | 191.5 kb | Distal (>10kb) Multiome | 618 | |
| chr16:2,152,861–2,153,999 | 194.1 kb | Distal (>10kb) Multiome | 734 | |
| chr16:2,154,834–2,156,329 | 196.0 kb | Distal (>10kb) Multiome | 932 | |
| chr16:2,178,140–2,179,722 | 219.3 kb | Distal (>10kb) Multiome | 318 | |
| chr16:2,205,129–2,206,297 | 246.0 kb | Distal (>10kb) Multiome | 887 | |
| chr16:2,214,212–2,215,803 | 255.5 kb | Distal (>10kb) Multiome | 953 | |
| chr16:2,223,095–2,224,285 | 263.9 kb | Distal (>10kb) Multiome | 918 | |
| chr16:2,251,044–2,252,460 | 292.1 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the NDUFB10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.