NDOR1
NADPH dependent diflavin oxidoreductase 1 | CIAE1, NR1, bA350O14.9

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Biological processes 31 terms
FAD binding (GO:0071949)FMN binding (GO:0010181)FMN binding (GO:0010181)FMN binding (GO:0010181)NADP binding (GO:0050661)NADP binding (GO:0050661)NADPH binding (GO:0070402)NADPH-hemoprotein reductase activity (GO:0003958)NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity (GO:0160246)NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity (GO:0160246)cellular response to oxidative stress (GO:0034599)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)electron transfer activity (GO:0009055)electron transport chain (GO:0022900)flavin adenine dinucleotide binding (GO:0050660)flavin adenine dinucleotide binding (GO:0050660)iron-sulfur cluster assembly (GO:0016226)iron-sulfur cluster assembly (GO:0016226)iron-sulfur cluster assembly (GO:0016226)nucleus (GO:0005634)oxidoreductase activity (GO:0016491)oxidoreductase activity (GO:0016491)oxidoreductase activity, acting on NAD(P)H (GO:0016651)oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor (GO:0016653)perinuclear region of cytoplasm (GO:0048471)protein binding (GO:0005515)
Expression (TPM)
NDOR1 — as a Regulated Gene

TFs regulating NDOR1 0 TFs

Transcription factors with Perturb-seq knockdown data for NDOR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDOR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NDOR1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDOR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr9:136,943,250–136,945,621 261.0 kb Distal (>10kb) Multiome 883
chr9:136,949,631–136,950,846 255.5 kb Distal (>10kb) Multiome 776
chr9:136,977,106–136,980,430 227.2 kb Distal (>10kb) Multiome 413
chr9:136,991,827–136,993,248 213.3 kb Distal (>10kb) Multiome 720
chr9:137,027,536–137,029,054 177.4 kb Distal (>10kb) Multiome 539
chr9:137,029,231–137,029,652 176.1 kb Distal (>10kb) Multiome 386
chr9:137,045,334–137,046,838 159.1 kb Distal (>10kb) Multiome 829
chr9:137,053,352–137,054,892 151.5 kb Distal (>10kb) Multiome 544
chr9:137,067,810–137,068,494 137.6 kb Distal (>10kb) Multiome HiCAR 492
chr9:137,069,879–137,071,138 135.0 kb Distal (>10kb) Multiome 703
chr9:137,076,758–137,078,723 128.2 kb Distal (>10kb) Multiome 530
chr9:137,085,844–137,087,716 118.8 kb Distal (>10kb) Multiome 890
chr9:137,129,244–137,130,499 75.9 kb Distal (>10kb) Multiome HiCAR 823
chr9:137,167,984–137,170,155 36.2 kb Distal (>10kb) Multiome 560
chr9:137,188,099–137,189,538 16.9 kb Distal (>10kb) Multiome 954
chr9:137,199,427–137,200,043 5.6 kb Proximal (<10kb) 193
chr9:137,200,175–137,201,689 4.8 kb Proximal (<10kb) Multiome 856
chr9:137,205,371–137,205,975 32 bp At TSS Multiome 758
chr9:137,221,373–137,224,294 16.2 kb Distal (>10kb) Multiome HiCAR 843
chr9:137,227,249–137,228,051 22.0 kb Distal (>10kb) Multiome HiCAR 533
chr9:137,236,161–137,237,143 31.0 kb Distal (>10kb) Multiome 748
chr9:137,239,991–137,242,933 35.4 kb Distal (>10kb) Multiome 1117
chr9:137,243,659–137,245,307 38.6 kb Distal (>10kb) Multiome 471
chr9:137,253,801–137,256,036 49.6 kb Distal (>10kb) Multiome 843
chr9:137,280,593–137,281,861 75.5 kb Distal (>10kb) Multiome 223
chr9:137,294,859–137,296,916 89.8 kb Distal (>10kb) Multiome 501
chr9:137,300,591–137,303,141 96.8 kb Distal (>10kb) Multiome 790
chr9:137,316,104–137,316,916 110.6 kb Distal (>10kb) Multiome 395
chr9:137,406,843–137,407,556 201.5 kb Distal (>10kb) Multiome 427
chr9:137,422,664–137,424,024 217.6 kb Distal (>10kb) Multiome 896
chr9:137,441,270–137,441,970 235.9 kb Distal (>10kb) Multiome 568
chr9:137,453,153–137,455,543 248.4 kb Distal (>10kb) Multiome 727
chr9:137,458,468–137,459,887 253.7 kb Distal (>10kb) Multiome 613
chr9:137,461,555–137,462,160 256.2 kb Distal (>10kb) Multiome 284

Genome Browser

Genomic view of the NDOR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr9:136,933,250 – 137,472,160
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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