This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NCS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,191,300–128,192,050 | 1980.7 kb | Distal (>10kb) Multiome HiCAR | 865 | |
| chr9:128,203,004–128,204,704 | 1968.0 kb | Distal (>10kb) Multiome HiCAR | 690 | |
| chr9:130,042,478–130,043,723 | 129.1 kb | Distal (>10kb) Multiome | 793 | |
| chr9:130,171,788–130,172,513 | 96 bp | At TSS Multiome | 253 | |
| chr9:130,214,219–130,214,715 | 42.1 kb | Distal (>10kb) Multiome | 146 | |
| chr9:130,243,058–130,243,650 | 70.9 kb | Distal (>10kb) Multiome | 380 | |
| chr9:130,265,477–130,266,015 | 93.3 kb | Distal (>10kb) Multiome | 214 | |
| chr9:130,433,040–130,433,900 | 261.0 kb | Distal (>10kb) Multiome | 543 | |
| chr9:130,444,394–130,446,012 | 272.4 kb | Distal (>10kb) Multiome | 568 | |
| chr9:130,446,125–130,446,731 | 274.1 kb | Distal (>10kb) Multiome | 326 |
Genomic view of the NCS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.