Transcription factors with Perturb-seq knockdown data for NCAPD2P1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCAPD2P1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCAPD2P1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:34,748,265–34,748,700 | 3.4 kb | Proximal (<10kb) | 575 | |
| chr7:34,751,761–34,752,878 | at TSS | At TSS | 178 | |
| chr7:34,756,046–34,756,215 | 4.0 kb | Proximal (<10kb) | 137 | |
| chr7:34,759,414–34,759,941 | 7.4 kb | Proximal (<10kb) | 208 |
Genomic view of the NCAPD2P1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.