Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]
Transcription factors with Perturb-seq knockdown data for NCAN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCAN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCAN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:18,918,971–18,919,972 | 292.4 kb | Distal (>10kb) Multiome | 828 | |
| chr19:18,932,038–18,933,012 | 279.4 kb | Distal (>10kb) Multiome | 312 | |
| chr19:18,940,835–18,941,417 | 270.6 kb | Distal (>10kb) Multiome | 336 | |
| chr19:19,032,820–19,034,059 | 178.3 kb | Distal (>10kb) Multiome | 944 | |
| chr19:19,063,253–19,064,386 | 148.2 kb | Distal (>10kb) Multiome | 781 | |
| chr19:19,105,310–19,106,514 | 106.2 kb | Distal (>10kb) Multiome | 447 | |
| chr19:19,110,429–19,110,857 | 101.3 kb | Distal (>10kb) Multiome | 131 | |
| chr19:19,119,998–19,121,362 | 91.4 kb | Distal (>10kb) Multiome | 304 | |
| chr19:19,138,171–19,138,698 | 73.5 kb | Distal (>10kb) Multiome | 642 | |
| chr19:19,170,055–19,170,692 | 41.6 kb | Distal (>10kb) Multiome | 403 | |
| chr19:19,191,912–19,193,209 | 19.3 kb | Distal (>10kb) Multiome | 939 | |
| chr19:19,202,895–19,203,773 | 8.5 kb | Proximal (<10kb) Multiome | 599 | |
| chr19:19,215,041–19,215,249 | 3.1 kb | Proximal (<10kb) | 422 | |
| chr19:19,224,938–19,225,553 | 13.2 kb | Distal (>10kb) Multiome | 646 | |
| chr19:19,261,403–19,261,973 | 49.8 kb | Distal (>10kb) Multiome | 205 | |
| chr19:19,272,869–19,273,464 | 61.2 kb | Distal (>10kb) Multiome | 236 | |
| chr19:19,320,030–19,321,531 | 108.7 kb | Distal (>10kb) Multiome | 839 | |
| chr19:19,384,944–19,386,424 | 173.7 kb | Distal (>10kb) Multiome | 788 | |
| chr19:19,405,072–19,406,890 | 193.7 kb | Distal (>10kb) Multiome | 1014 | |
| chr19:19,461,886–19,462,726 | 250.4 kb | Distal (>10kb) Multiome | 345 |
Genomic view of the NCAN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.