This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for NAPG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAPG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAPG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:10,131,837–10,132,366 | 394.1 kb | Distal (>10kb) Multiome HiCAR | 250 | |
| chr18:10,406,100–10,406,886 | 119.7 kb | Distal (>10kb) Multiome | 207 | |
| chr18:10,453,745–10,455,261 | 71.5 kb | Distal (>10kb) Multiome | 375 | |
| chr18:10,520,201–10,520,407 | 5.5 kb | Proximal (<10kb) | 272 | |
| chr18:10,525,772–10,526,686 | 2 bp | At TSS Multiome | 732 |
Genomic view of the NAPG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.