This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for NAPA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAPA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAPA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:47,225,386–47,231,990 | 287.2 kb | Distal (>10kb) Multiome | 1389 | |
| chr19:47,240,827–47,241,572 | 273.8 kb | Distal (>10kb) Multiome | 616 | |
| chr19:47,242,713–47,243,645 | 271.9 kb | Distal (>10kb) Multiome | 568 | |
| chr19:47,243,835–47,244,896 | 270.7 kb | Distal (>10kb) Multiome | 1001 | |
| chr19:47,256,041–47,258,057 | 258.0 kb | Distal (>10kb) Multiome | 907 | |
| chr19:47,272,778–47,275,890 | 241.7 kb | Distal (>10kb) Multiome | 931 | |
| chr19:47,348,695–47,349,758 | 165.8 kb | Distal (>10kb) Multiome | 766 | |
| chr19:47,406,825–47,407,408 | 107.7 kb | Distal (>10kb) Multiome | 333 | |
| chr19:47,427,132–47,428,809 | 87.8 kb | Distal (>10kb) Multiome | 506 | |
| chr19:47,429,865–47,430,531 | 84.7 kb | Distal (>10kb) Multiome | 438 | |
| chr19:47,447,043–47,448,262 | 67.4 kb | Distal (>10kb) Multiome | 510 | |
| chr19:47,471,631–47,472,340 | 43.0 kb | Distal (>10kb) Multiome | 500 | |
| chr19:47,479,940–47,480,772 | 34.9 kb | Distal (>10kb) Multiome | 147 | |
| chr19:47,483,636–47,484,543 | 30.9 kb | Distal (>10kb) Multiome | 841 | |
| chr19:47,514,152–47,515,901 | 254 bp | At TSS Multiome | 895 | |
| chr19:47,600,223–47,600,983 | 85.5 kb | Distal (>10kb) Multiome | 807 | |
| chr19:47,607,980–47,609,479 | 93.8 kb | Distal (>10kb) Multiome | 832 | |
| chr19:47,647,803–47,648,987 | 133.4 kb | Distal (>10kb) Multiome | 693 | |
| chr19:47,697,956–47,698,391 | 183.2 kb | Distal (>10kb) Multiome HiCAR | 453 | |
| chr19:47,729,949–47,730,505 | 215.2 kb | Distal (>10kb) Multiome | 425 | |
| chr19:47,743,369–47,743,911 | 228.7 kb | Distal (>10kb) Multiome | 929 | |
| chr19:47,745,136–47,745,915 | 230.5 kb | Distal (>10kb) Multiome | 784 | |
| chr19:47,765,762–47,766,380 | 251.0 kb | Distal (>10kb) Multiome | 296 | |
| chr19:47,770,120–47,770,789 | 255.4 kb | Distal (>10kb) Multiome | 127 | |
| chr19:47,778,102–47,779,241 | 263.5 kb | Distal (>10kb) Multiome | 845 | |
| chr19:47,788,509–47,789,220 | 273.7 kb | Distal (>10kb) Multiome | 365 | |
| chr19:47,790,277–47,790,794 | 275.4 kb | Distal (>10kb) Multiome | 275 |
Genomic view of the NAPA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.