Enables N-acylneuraminate-9-phosphatase activity. Involved in CMP-N-acetylneuraminate biosynthetic process; N-acetylneuraminate biosynthetic process; and glycosylation. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NANP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NANP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NANP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:25,389,726–25,391,241 | 233.1 kb | Distal (>10kb) Multiome | 1021 | |
| chr20:25,407,111–25,408,013 | 216.3 kb | Distal (>10kb) Multiome | 1021 | |
| chr20:25,550,130–25,551,344 | 73.2 kb | Distal (>10kb) Multiome | 207 | |
| chr20:25,584,579–25,586,173 | 38.5 kb | Distal (>10kb) Multiome | 890 | |
| chr20:25,622,823–25,624,816 | 5 bp | At TSS Multiome | 1127 | |
| chr20:25,626,372–25,627,565 | 2.8 kb | Proximal (<10kb) Multiome | 102 | |
| chr20:25,695,981–25,697,222 | 72.8 kb | Distal (>10kb) Multiome | 1015 |
Genomic view of the NANP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.