Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Located in chromatin; mitochondrion; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NACC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NACC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NACC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:135,906,558–135,908,509 | 187.7 kb | Distal (>10kb) Multiome | 772 | |
| chr9:135,960,610–135,961,627 | 133.9 kb | Distal (>10kb) Multiome | 697 | |
| chr9:135,992,635–135,993,405 | 102.2 kb | Distal (>10kb) Multiome | 684 | |
| chr9:136,051,068–136,051,829 | 43.8 kb | Distal (>10kb) Multiome | 353 | |
| chr9:136,094,003–136,094,338 | 950 bp | At TSS | 518 | |
| chr9:136,094,901–136,095,992 | 187 bp | At TSS Multiome | 445 | |
| chr9:136,109,321–136,110,010 | 14.4 kb | Distal (>10kb) Multiome | 643 | |
| chr9:136,117,952–136,119,826 | 23.5 kb | Distal (>10kb) Multiome | 931 | |
| chr9:136,132,442–136,133,645 | 37.9 kb | Distal (>10kb) Multiome | 343 | |
| chr9:136,245,219–136,246,310 | 150.6 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,267,002–136,267,928 | 172.1 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,327,140–136,327,919 | 232.3 kb | Distal (>10kb) Multiome | 310 | |
| chr9:136,342,464–136,343,245 | 247.6 kb | Distal (>10kb) Multiome | 326 | |
| chr9:136,362,899–136,364,677 | 268.1 kb | Distal (>10kb) Multiome | 969 |
Genomic view of the NACC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.