NACC1

nucleus accumbens associated 1 | BEND8, BTBD30, NAC-1, NAC1, BTBD14B

This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]

Biological processes 20 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cytoplasm (GO:0005737)cytosol (GO:0005829)histone deacetylase binding (GO:0042826)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear lumen (GO:0031981)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of cell population proliferation (GO:0008284)protein binding (GO:0005515)regulation of cell population proliferation (GO:0042127)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating NACC1 0 TFs

Transcription factors with Perturb-seq knockdown data for NACC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NACC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NACC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NACC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,825,565–12,826,186	291.0 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	284.2 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	282.9 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	278.4 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	276.0 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	269.1 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	249.2 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	243.5 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	235.4 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	231.5 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	225.9 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	203.5 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	197.5 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	183.1 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	178.4 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	170.9 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	159.6 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	151.4 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	133.2 kb	Distal (>10kb) Multiome HiCAR	688
chr19:13,051,485–13,052,169	65.0 kb	Distal (>10kb) Multiome	649
chr19:13,061,195–13,061,672	55.4 kb	Distal (>10kb) Multiome	544
chr19:13,069,469–13,070,306	47.0 kb	Distal (>10kb) Multiome	334
chr19:13,093,620–13,094,260	22.9 kb	Distal (>10kb) Multiome	411
chr19:13,095,079–13,096,870	21.4 kb	Distal (>10kb) Multiome	501
chr19:13,102,495–13,103,074	14.0 kb	Distal (>10kb) Multiome	606
chr19:13,116,411–13,117,080	142 bp	At TSS Multiome	812
chr19:13,117,979–13,119,416	1.4 kb	Proximal (<10kb) Multiome	699
chr19:13,149,468–13,156,577	33.4 kb	Distal (>10kb) Multiome	1333
chr19:13,162,579–13,165,523	47.9 kb	Distal (>10kb) Multiome	1112
chr19:13,167,359–13,168,023	50.9 kb	Distal (>10kb) Multiome	764

Genome Browser

Genomic view of the NACC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.