Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NAB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:190,407,333–190,409,184 | 240.5 kb | Distal (>10kb) Multiome | 669 | |
| chr2:190,533,850–190,535,346 | 114.2 kb | Distal (>10kb) Multiome | 1040 | |
| chr2:190,636,515–190,638,167 | 11.6 kb | Distal (>10kb) Multiome | 219 | |
| chr2:190,647,806–190,650,037 | 110 bp | At TSS Multiome | 864 | |
| chr2:190,679,871–190,680,604 | 31.5 kb | Distal (>10kb) Multiome | 345 | |
| chr2:190,860,849–190,861,826 | 212.5 kb | Distal (>10kb) Multiome | 191 | |
| chr2:190,869,557–190,870,549 | 221.1 kb | Distal (>10kb) Multiome | 91 | |
| chr2:190,880,124–190,882,292 | 233.1 kb | Distal (>10kb) Multiome | 1086 |
Genomic view of the NAB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.