Enables DNA-binding transcription factor binding activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including N-acylethanolamine metabolic process; N-acylphosphatidylethanolamine metabolic process; and sphingosine metabolic process. Located in lysosome and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NAAA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAAA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAAA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:75,672,443–75,674,197 | 267.5 kb | Distal (>10kb) Multiome | 969 | |
| chr4:75,704,833–75,705,758 | 235.6 kb | Distal (>10kb) Multiome | 191 | |
| chr4:75,723,996–75,725,607 | 216.5 kb | Distal (>10kb) Multiome | 996 | |
| chr4:75,848,100–75,848,739 | 92.6 kb | Distal (>10kb) Multiome | 281 | |
| chr4:75,939,639–75,941,475 | 800 bp | At TSS Multiome | 762 | |
| chr4:75,990,621–75,991,159 | 49.9 kb | Distal (>10kb) Multiome | 782 | |
| chr4:76,087,045–76,087,527 | 146.3 kb | Distal (>10kb) Multiome | 438 | |
| chr4:76,147,405–76,148,870 | 207.4 kb | Distal (>10kb) Multiome | 1076 | |
| chr4:76,212,911–76,214,625 | 272.8 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the NAAA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.