Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MZT2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MZT2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MZT2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:131,153,640–131,154,672 | 338.2 kb | Distal (>10kb) Multiome HiCAR | 397 | |
| chr2:131,491,539–131,491,749 | 585 bp | At TSS | 26 | |
| chr2:131,492,005–131,493,530 | 461 bp | At TSS Multiome | 829 | |
| chr2:131,527,544–131,528,836 | 35.5 kb | Distal (>10kb) Multiome | 152 | |
| chr2:131,672,051–131,674,269 | 180.4 kb | Distal (>10kb) Multiome | 465 | |
| chr2:131,681,926–131,683,271 | 190.1 kb | Distal (>10kb) Multiome | 661 |
Genomic view of the MZT2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.