The protein encoded by this gene is specifically expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for MYOZ3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYOZ3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYOZ3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:150,409,825–150,410,350 | 261.7 kb | Distal (>10kb) Multiome | 299 | |
| chr5:150,412,530–150,413,063 | 258.9 kb | Distal (>10kb) Multiome | 495 | |
| chr5:150,441,289–150,442,097 | 230.0 kb | Distal (>10kb) Multiome | 188 | |
| chr5:150,449,356–150,450,212 | 221.8 kb | Distal (>10kb) Multiome HiCAR | 1068 | |
| chr5:150,458,741–150,459,365 | 212.7 kb | Distal (>10kb) Multiome | 430 | |
| chr5:150,485,401–150,487,150 | 185.9 kb | Distal (>10kb) Multiome | 761 | |
| chr5:150,577,977–150,578,481 | 93.4 kb | Distal (>10kb) Multiome HiCAR | 149 | |
| chr5:150,624,424–150,625,067 | 46.9 kb | Distal (>10kb) Multiome | 250 | |
| chr5:150,656,143–150,657,405 | 15.0 kb | Distal (>10kb) Multiome | 607 | |
| chr5:150,670,030–150,670,981 | 1.1 kb | Proximal (<10kb) Multiome | 69 | |
| chr5:150,671,571–150,672,919 | 739 bp | At TSS Multiome | 303 | |
| chr5:150,700,548–150,701,464 | 29.4 kb | Distal (>10kb) Multiome HiCAR | 858 | |
| chr5:150,758,281–150,759,438 | 87.2 kb | Distal (>10kb) Multiome | 902 | |
| chr5:150,778,240–150,779,492 | 107.4 kb | Distal (>10kb) Multiome | 723 | |
| chr5:150,783,348–150,783,999 | 112.0 kb | Distal (>10kb) Multiome | 435 | |
| chr5:150,801,105–150,801,901 | 129.9 kb | Distal (>10kb) Multiome | 382 |
Genomic view of the MYOZ3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.