The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MYO3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:24,208,276–24,209,690 | 1725.2 kb | Distal (>10kb) Multiome HiCAR | 528 | |
| chr10:25,766,260–25,767,199 | 167.4 kb | Distal (>10kb) Multiome | 372 | |
| chr10:25,933,585–25,935,356 | 9 bp | At TSS Multiome | 425 | |
| chr10:26,213,352–26,215,371 | 280.0 kb | Distal (>10kb) Multiome | 288 | |
| chr10:26,215,641–26,217,078 | 282.1 kb | Distal (>10kb) Multiome | 315 | |
| chr10:26,217,323–26,218,515 | 283.8 kb | Distal (>10kb) Multiome | 231 | |
| chr10:26,222,412–26,223,241 | 288.6 kb | Distal (>10kb) Multiome | 164 |
Genomic view of the MYO3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.