Transcription factors with Perturb-seq knockdown data for MYO1B-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO1B-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO1B-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:191,013,523–191,014,882 | 231.9 kb | Distal (>10kb) Multiome | 1090 | |
| chr2:191,020,168–191,020,996 | 225.7 kb | Distal (>10kb) Multiome | 1169 | |
| chr2:191,049,645–191,052,413 | 196.0 kb | Distal (>10kb) Multiome | 448 | |
| chr2:191,150,245–191,151,620 | 95.2 kb | Distal (>10kb) Multiome | 430 | |
| chr2:191,155,578–191,156,319 | 90.3 kb | Distal (>10kb) Multiome | 129 | |
| chr2:191,166,129–191,168,453 | 79.4 kb | Distal (>10kb) Multiome | 369 | |
| chr2:191,244,968–191,246,655 | 32 bp | At TSS Multiome | 961 | |
| chr2:191,246,812–191,247,266 | 640 bp | At TSS | 55 | |
| chr2:191,250,888–191,251,582 | 5.1 kb | Proximal (<10kb) Multiome | 95 | |
| chr2:191,301,718–191,302,748 | 56.0 kb | Distal (>10kb) Multiome | 115 | |
| chr2:191,478,933–191,479,885 | 233.4 kb | Distal (>10kb) Multiome | 223 |
Genomic view of the MYO1B-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.