Involved in myoblast fusion involved in skeletal muscle regeneration. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Implicated in Carey-Fineman-Ziter syndrome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MYMX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYMX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYMX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:44,216,763–44,217,285 | at TSS | At TSS | 139 | |
| chr6:44,217,417–44,217,710 | 492 bp | At TSS | 236 | |
| chr6:44,218,945–44,220,120 | 2.0 kb | Proximal (<10kb) | 799 | |
| chr6:44,221,398–44,222,005 | 4.5 kb | Proximal (<10kb) | 538 | |
| chr6:44,223,166–44,224,465 | 6.2 kb | Proximal (<10kb) | 783 | |
| chr6:44,225,806–44,226,064 | 8.9 kb | Proximal (<10kb) | 294 |
Genomic view of the MYMX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.