This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for MYH14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYH14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYH14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,928,884–49,930,473 | 275.5 kb | Distal (>10kb) Multiome | 1141 | |
| chr19:49,987,157–49,987,669 | 218.1 kb | Distal (>10kb) Multiome | 1095 | |
| chr19:50,024,875–50,026,285 | 179.8 kb | Distal (>10kb) Multiome | 1137 | |
| chr19:50,147,523–50,148,432 | 57.3 kb | Distal (>10kb) Multiome | 615 | |
| chr19:50,203,034–50,204,072 | 1.9 kb | Proximal (<10kb) Multiome | 363 | |
| chr19:50,205,195–50,205,903 | 52 bp | At TSS Multiome | 364 | |
| chr19:50,311,942–50,312,908 | 106.8 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 108.8 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 110.6 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 120.3 kb | Distal (>10kb) Multiome | 748 | |
| chr19:50,328,019–50,330,066 | 123.9 kb | Distal (>10kb) Multiome | 699 | |
| chr19:50,330,341–50,331,411 | 125.4 kb | Distal (>10kb) Multiome | 479 | |
| chr19:50,332,395–50,334,325 | 128.1 kb | Distal (>10kb) Multiome | 907 | |
| chr19:50,368,630–50,369,092 | 163.5 kb | Distal (>10kb) Multiome | 311 | |
| chr19:50,376,225–50,377,452 | 171.2 kb | Distal (>10kb) Multiome | 931 | |
| chr19:50,383,444–50,384,805 | 178.8 kb | Distal (>10kb) Multiome | 863 | |
| chr19:50,414,638–50,415,204 | 209.5 kb | Distal (>10kb) Multiome | 377 | |
| chr19:50,431,430–50,432,503 | 226.4 kb | Distal (>10kb) Multiome | 530 | |
| chr19:50,475,914–50,477,044 | 271.1 kb | Distal (>10kb) Multiome | 622 |
Genomic view of the MYH14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.