Enables 3'-5'-RNA exonuclease activity. Involved in mRNA processing; mitochondrial RNA metabolic process; and rRNA processing. Located in mitochondrion and nucleus. Is active in mitochondrial matrix; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:53,005,438–53,007,356 | 293.4 kb | Distal (>10kb) Multiome | 995 | |
| chr12:53,046,385–53,049,295 | 252.3 kb | Distal (>10kb) Multiome | 793 | |
| chr12:53,049,465–53,050,530 | 249.8 kb | Distal (>10kb) Multiome | 565 | |
| chr12:53,053,508–53,054,860 | 245.3 kb | Distal (>10kb) Multiome | 646 | |
| chr12:53,078,790–53,079,991 | 220.3 kb | Distal (>10kb) Multiome | 835 | |
| chr12:53,097,544–53,098,160 | 202.0 kb | Distal (>10kb) Multiome | 515 | |
| chr12:53,174,900–53,175,484 | 124.5 kb | Distal (>10kb) Multiome | 474 | |
| chr12:53,179,987–53,181,456 | 119.0 kb | Distal (>10kb) Multiome | 930 | |
| chr12:53,219,787–53,222,151 | 78.6 kb | Distal (>10kb) Multiome HiCAR | 828 | |
| chr12:53,231,703–53,233,098 | 67.4 kb | Distal (>10kb) Multiome | 464 | |
| chr12:53,251,461–53,252,566 | 47.7 kb | Distal (>10kb) Multiome HiCAR | 825 | |
| chr12:53,268,046–53,268,600 | 31.5 kb | Distal (>10kb) Multiome | 709 | |
| chr12:53,295,142–53,295,823 | 4.3 kb | Proximal (<10kb) Multiome | 706 | |
| chr12:53,299,515–53,300,187 | 27 bp | At TSS Multiome | 849 | |
| chr12:53,321,051–53,322,029 | 21.8 kb | Distal (>10kb) Multiome | 935 | |
| chr12:53,324,682–53,326,037 | 25.2 kb | Distal (>10kb) Multiome | 840 | |
| chr12:53,344,427–53,345,660 | 45.3 kb | Distal (>10kb) Multiome | 645 | |
| chr12:53,370,910–53,371,893 | 71.7 kb | Distal (>10kb) Multiome | 861 | |
| chr12:53,378,839–53,381,297 | 80.8 kb | Distal (>10kb) Multiome | 895 | |
| chr12:53,381,689–53,382,262 | 82.3 kb | Distal (>10kb) Multiome | 264 | |
| chr12:53,421,253–53,422,044 | 121.9 kb | Distal (>10kb) Multiome | 431 | |
| chr12:53,440,979–53,441,838 | 141.9 kb | Distal (>10kb) Multiome | 779 | |
| chr12:53,451,563–53,453,067 | 152.3 kb | Distal (>10kb) Multiome | 999 | |
| chr12:53,492,147–53,494,149 | 193.4 kb | Distal (>10kb) Multiome HiCAR | 702 | |
| chr12:53,498,714–53,500,111 | 199.7 kb | Distal (>10kb) Multiome | 454 | |
| chr12:53,500,242–53,501,839 | 201.3 kb | Distal (>10kb) Multiome | 1010 |
Genomic view of the MYG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.