This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for MYD88. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYD88 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYD88, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:37,859,865–37,862,804 | 278.1 kb | Distal (>10kb) Multiome | 1005 | |
| chr3:37,993,686–37,994,594 | 144.4 kb | Distal (>10kb) Multiome | 519 | |
| chr3:37,998,336–37,999,630 | 139.6 kb | Distal (>10kb) Multiome | 510 | |
| chr3:38,003,084–38,004,028 | 135.1 kb | Distal (>10kb) Multiome | 352 | |
| chr3:38,023,878–38,025,927 | 113.7 kb | Distal (>10kb) Multiome HiCAR | 762 | |
| chr3:38,028,710–38,030,184 | 109.0 kb | Distal (>10kb) Multiome HiCAR | 378 | |
| chr3:38,039,093–38,039,944 | 99.3 kb | Distal (>10kb) Multiome | 357 | |
| chr3:38,136,419–38,139,307 | 1.4 kb | Proximal (<10kb) Multiome | 989 | |
| chr3:38,164,619–38,166,160 | 26.6 kb | Distal (>10kb) Multiome | 1040 | |
| chr3:38,345,594–38,347,388 | 208.2 kb | Distal (>10kb) Multiome HiCAR | 971 | |
| chr3:38,495,771–38,496,881 | 357.7 kb | Distal (>10kb) Multiome HiCAR | 764 | |
| chr3:38,649,012–38,650,212 | 511.0 kb | Distal (>10kb) Multiome HiCAR | 437 | |
| chr3:38,651,034–38,651,663 | 512.7 kb | Distal (>10kb) Multiome HiCAR | 351 |
Genomic view of the MYD88 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.