MYBL1

MYB proto-oncogene like 1 | A-myb, AMYB

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 21 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)male meiosis I (GO:0007141)mitotic cell cycle (GO:0000278)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of piRNA transcription (GO:0140543)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)regulation of DNA-templated transcription (GO:0006355)spermatogenesis (GO:0007283)

Expression (TPM)

TFs regulating MYBL1 0 TFs

Transcription factors with Perturb-seq knockdown data for MYBL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYBL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MYBL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYBL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:66,348,361–66,349,034	264.7 kb	Distal (>10kb) Multiome	176
chr8:66,428,113–66,430,401	184.5 kb	Distal (>10kb) Multiome	921
chr8:66,431,895–66,432,840	180.8 kb	Distal (>10kb) Multiome	609
chr8:66,438,980–66,439,800	174.1 kb	Distal (>10kb) Multiome HiCAR	484
chr8:66,512,582–66,513,139	100.5 kb	Distal (>10kb) Multiome	239
chr8:66,612,352–66,614,219	80 bp	At TSS Multiome	862
chr8:66,666,261–66,667,884	54.1 kb	Distal (>10kb) Multiome	889
chr8:66,712,294–66,713,281	99.4 kb	Distal (>10kb) Multiome	648
chr8:66,774,026–66,775,860	161.9 kb	Distal (>10kb) Multiome	957
chr8:66,870,495–66,871,236	257.5 kb	Distal (>10kb) Multiome	352
chr8:68,330,148–68,332,646	1717.7 kb	Distal (>10kb) Multiome HiCAR	393

Genome Browser

Genomic view of the MYBL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.