MUL1
mitochondrial E3 ubiquitin protein ligase 1 | FLJ12875, GIDE, MAPL, MULAN, RNF218, C1orf166

Enables several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including cellular response to exogenous dsRNA; negative regulation of defense response; and regulation of mitochondrion organization. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and peroxisome. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 50 terms
SUMO transferase activity (GO:0019789)TOM complex (GO:0140596)axon (GO:0030424)cellular response to exogenous dsRNA (GO:0071360)identical protein binding (GO:0042802)membrane (GO:0016020)mitochondrial fission (GO:0000266)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion localization (GO:0051646)negative regulation of chemokine (C-C motif) ligand 5 production (GO:0071650)negative regulation of defense response to virus by host (GO:0050689)negative regulation of innate immune response (GO:0045824)negative regulation of mitochondrial fusion (GO:0010637)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)negative regulation of type I interferon-mediated signaling pathway (GO:0060339)neuronal cell body (GO:0043025)p53 binding (GO:0002039)peroxisome (GO:0005777)peroxisome (GO:0005777)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of dendrite extension (GO:1903861)positive regulation of developmental process (GO:0051094)positive regulation of mitochondrial fission (GO:0090141)positive regulation of mitochondrial fission (GO:0090141)positive regulation of protein sumoylation (GO:0033235)positive regulation of type 2 mitophagy (GO:1905091)protein binding (GO:0005515)protein destabilization (GO:0031648)protein polyubiquitination (GO:0000209)protein stabilization (GO:0050821)protein stabilization (GO:0050821)protein sumoylation (GO:0016925)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)regulation of anatomical structure morphogenesis (GO:0022603)regulation of mitochondrial membrane potential (GO:0051881)regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028)regulation of mitochondrion organization (GO:0010821)regulation of protein stability (GO:0031647)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase binding (GO:0031625)ubiquitin-protein transferase activity (GO:0004842)
Expression (TPM)
MUL1 — as a Regulated Gene

TFs regulating MUL1 0 TFs

Transcription factors with Perturb-seq knockdown data for MUL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MUL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MUL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MUL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:20,213,009–20,213,518 295.0 kb Distal (>10kb) Multiome 361
chr1:20,290,425–20,291,141 217.4 kb Distal (>10kb) Multiome 203
chr1:20,342,875–20,344,326 164.5 kb Distal (>10kb) Multiome 261
chr1:20,366,975–20,367,437 140.9 kb Distal (>10kb) Multiome 164
chr1:20,402,741–20,403,363 105.2 kb Distal (>10kb) Multiome 165
chr1:20,430,474–20,430,904 77.5 kb Distal (>10kb) Multiome 217
chr1:20,485,233–20,485,959 22.5 kb Distal (>10kb) Multiome 348
chr1:20,486,131–20,487,438 21.3 kb Distal (>10kb) Multiome 760
chr1:20,493,822–20,494,241 14.0 kb Distal (>10kb) Multiome 430
chr1:20,507,717–20,508,432 9 bp At TSS Multiome 811
chr1:20,552,019–20,553,890 44.2 kb Distal (>10kb) Multiome 518
chr1:20,588,675–20,590,358 80.9 kb Distal (>10kb) Multiome 431
chr1:20,625,186–20,625,881 117.3 kb Distal (>10kb) Multiome 123
chr1:20,633,024–20,634,989 125.7 kb Distal (>10kb) Multiome 759
chr1:20,661,099–20,662,130 153.4 kb Distal (>10kb) Multiome 784
chr1:20,696,319–20,697,384 188.7 kb Distal (>10kb) Multiome 727
chr1:20,717,384–20,718,370 209.7 kb Distal (>10kb) Multiome 440
chr1:20,731,726–20,733,330 224.1 kb Distal (>10kb) Multiome 718
chr1:20,786,021–20,787,857 278.8 kb Distal (>10kb) Multiome 963

Genome Browser

Genomic view of the MUL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:20,203,009 – 20,797,857
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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