Transcription factors with Perturb-seq knockdown data for MTUS1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTUS1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTUS1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:17,576,233–17,578,047 | 223.8 kb | Distal (>10kb) Multiome | 651 | |
| chr8:17,608,058–17,609,221 | 192.5 kb | Distal (>10kb) Multiome | 337 | |
| chr8:17,748,883–17,749,493 | 52.1 kb | Distal (>10kb) Multiome | 49 | |
| chr8:17,800,137–17,800,300 | 1.0 kb | Proximal (<10kb) | 191 | |
| chr8:17,800,593–17,801,971 | 45 bp | At TSS Multiome | 778 | |
| chr8:17,912,201–17,912,908 | 111.3 kb | Distal (>10kb) Multiome | 360 | |
| chr8:17,922,394–17,924,221 | 121.5 kb | Distal (>10kb) Multiome | 992 | |
| chr8:18,083,277–18,085,104 | 282.8 kb | Distal (>10kb) Multiome | 1029 |
Genomic view of the MTUS1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.