Involved in negative regulation of NF-kappaB transcription factor activity; positive regulation of MAPK cascade; and positive regulation of megakaryocyte differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTURN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTURN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTURN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:29,883,518–29,884,842 | 250.8 kb | Distal (>10kb) Multiome | 244 | |
| chr7:29,988,902–29,990,326 | 145.2 kb | Distal (>10kb) Multiome | 631 | |
| chr7:30,026,273–30,027,418 | 108.2 kb | Distal (>10kb) Multiome | 750 | |
| chr7:30,027,667–30,029,334 | 106.6 kb | Distal (>10kb) Multiome | 888 | |
| chr7:30,134,508–30,136,317 | 150 bp | At TSS Multiome | 663 | |
| chr7:30,284,014–30,286,043 | 149.5 kb | Distal (>10kb) Multiome | 943 |
Genomic view of the MTURN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.