Enables phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Located in cytoplasm and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTMR6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTMR6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTMR6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:25,047,042–25,047,668 | 240.3 kb | Distal (>10kb) Multiome | 177 | |
| chr13:25,170,532–25,171,326 | 116.6 kb | Distal (>10kb) Multiome | 133 | |
| chr13:25,286,940–25,287,682 | 84 bp | At TSS Multiome | 766 | |
| chr13:25,300,888–25,302,118 | 14.1 kb | Distal (>10kb) Multiome | 741 | |
| chr13:25,371,861–25,372,751 | 84.7 kb | Distal (>10kb) Multiome | 208 | |
| chr13:25,468,253–25,469,387 | 181.3 kb | Distal (>10kb) Multiome | 220 |
Genomic view of the MTMR6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.