MTG2

mitochondrial ribosome associated GTPase 2 | FLJ10741, ObgH1, dJ1005F21.2, GTPBP5

Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

Biological processes 20 terms

GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)magnesium ion binding (GO:0000287)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial large ribosomal subunit assembly (GO:1902775)mitochondrial large ribosomal subunit assembly (GO:1902775)mitochondrial large ribosomal subunit assembly (GO:1902775)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial ribosome (GO:0005761)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)regulation of mitochondrial translation (GO:0070129)regulation of respiratory system process (GO:0044065)

Expression (TPM)

TFs regulating MTG2 0 TFs

Transcription factors with Perturb-seq knockdown data for MTG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MTG2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:62,065,357–62,067,442	117.0 kb	Distal (>10kb) Multiome	841
chr20:62,121,331–62,123,419	60.8 kb	Distal (>10kb) Multiome	961
chr20:62,142,789–62,144,593	39.5 kb	Distal (>10kb) Multiome	841
chr20:62,182,546–62,183,326	29 bp	At TSS Multiome	1075
chr20:62,219,369–62,220,936	37.3 kb	Distal (>10kb) Multiome	599
chr20:62,237,918–62,239,210	55.4 kb	Distal (>10kb) Multiome	794
chr20:62,301,857–62,303,576	119.1 kb	Distal (>10kb) Multiome	1110
chr20:62,365,805–62,369,404	186.0 kb	Distal (>10kb) Multiome	960
chr20:62,386,553–62,387,309	204.0 kb	Distal (>10kb) Multiome	885
chr20:62,406,793–62,407,817	224.3 kb	Distal (>10kb) Multiome	935
chr20:62,475,060–62,476,807	293.0 kb	Distal (>10kb) Multiome	378

Genome Browser

Genomic view of the MTG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.