Enables rRNA binding activity. Predicted to be involved in mitochondrial ribosome assembly and mitochondrial transcription. Predicted to act upstream of or within several processes, including camera-type eye development; protein targeting to mitochondrion; and ribosome assembly. Located in cytosol and mitochondrion. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTERF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTERF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTERF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,818,573–240,821,401 | 283.2 kb | Distal (>10kb) Multiome | 419 | |
| chr2:240,832,084–240,832,795 | 269.9 kb | Distal (>10kb) Multiome | 307 | |
| chr2:240,902,359–240,903,515 | 199.4 kb | Distal (>10kb) Multiome | 217 | |
| chr2:240,997,873–240,999,416 | 103.8 kb | Distal (>10kb) Multiome | 439 | |
| chr2:241,009,658–241,010,603 | 92.2 kb | Distal (>10kb) Multiome | 314 | |
| chr2:241,102,057–241,102,727 | 99 bp | At TSS Multiome | 1072 | |
| chr2:241,148,805–241,150,972 | 47.1 kb | Distal (>10kb) Multiome | 897 | |
| chr2:241,217,134–241,217,954 | 115.4 kb | Distal (>10kb) Multiome | 700 | |
| chr2:241,272,147–241,273,188 | 170.5 kb | Distal (>10kb) Multiome | 539 | |
| chr2:241,314,756–241,316,790 | 213.2 kb | Distal (>10kb) Multiome | 1143 | |
| chr2:241,354,545–241,355,644 | 252.7 kb | Distal (>10kb) Multiome | 625 | |
| chr2:241,355,946–241,356,875 | 253.9 kb | Distal (>10kb) Multiome | 680 |
Genomic view of the MTERF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.