This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for MTCH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTCH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTCH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:36,863,795–36,864,608 | 122.1 kb | Distal (>10kb) Multiome | 173 | |
| chr6:36,874,493–36,875,198 | 111.4 kb | Distal (>10kb) Multiome | 1007 | |
| chr6:36,885,507–36,886,260 | 100.3 kb | Distal (>10kb) Multiome | 1011 | |
| chr6:36,984,814–36,985,161 | 1.1 kb | Proximal (<10kb) | 298 | |
| chr6:36,985,740–36,986,913 | 113 bp | At TSS Multiome | 926 | |
| chr6:37,051,534–37,052,487 | 65.5 kb | Distal (>10kb) Multiome | 766 | |
| chr6:37,059,338–37,060,100 | 73.5 kb | Distal (>10kb) Multiome | 824 | |
| chr6:37,071,640–37,072,385 | 85.7 kb | Distal (>10kb) Multiome | 281 | |
| chr6:37,102,284–37,103,074 | 116.5 kb | Distal (>10kb) Multiome | 855 | |
| chr6:37,125,557–37,126,783 | 139.9 kb | Distal (>10kb) Multiome | 528 | |
| chr6:37,137,028–37,138,409 | 151.6 kb | Distal (>10kb) Multiome | 735 | |
| chr6:37,141,368–37,141,988 | 155.5 kb | Distal (>10kb) Multiome | 239 | |
| chr6:37,168,853–37,171,673 | 183.7 kb | Distal (>10kb) Multiome | 1096 | |
| chr6:37,172,048–37,172,496 | 186.1 kb | Distal (>10kb) Multiome | 818 | |
| chr6:37,221,712–37,222,953 | 236.4 kb | Distal (>10kb) Multiome | 747 | |
| chr6:37,257,338–37,258,482 | 271.6 kb | Distal (>10kb) Multiome | 890 |
Genomic view of the MTCH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.