The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for MTARC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTARC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTARC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:219,839,143–219,840,267 | 908.5 kb | Distal (>10kb) Multiome HiCAR | 246 | |
| chr1:220,271,709–220,273,089 | 475.8 kb | Distal (>10kb) Multiome HiCAR | 984 | |
| chr1:220,338,584–220,339,585 | 409.3 kb | Distal (>10kb) Multiome HiCAR | 180 | |
| chr1:220,527,225–220,529,488 | 220.0 kb | Distal (>10kb) Multiome | 617 | |
| chr1:220,689,932–220,691,083 | 57.9 kb | Distal (>10kb) Multiome | 763 | |
| chr1:220,733,095–220,733,546 | 15.0 kb | Distal (>10kb) Multiome | 459 | |
| chr1:220,747,474–220,749,068 | 104 bp | At TSS Multiome | 799 | |
| chr1:220,750,296–220,750,742 | 2.0 kb | Proximal (<10kb) | 24 | |
| chr1:220,785,886–220,787,782 | 38.7 kb | Distal (>10kb) Multiome | 800 | |
| chr1:220,809,823–220,810,852 | 62.2 kb | Distal (>10kb) Multiome | 265 | |
| chr1:220,878,403–220,880,339 | 131.1 kb | Distal (>10kb) Multiome | 527 | |
| chr1:220,883,958–220,885,196 | 136.3 kb | Distal (>10kb) Multiome | 155 | |
| chr1:220,893,773–220,895,170 | 146.1 kb | Distal (>10kb) Multiome | 192 |
Genomic view of the MTARC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.