Transcription factors with Perturb-seq knockdown data for MTA1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTA1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTA1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:105,167,331–105,169,463 | 250.7 kb | Distal (>10kb) Multiome | 496 | |
| chr14:105,180,714–105,181,828 | 238.5 kb | Distal (>10kb) Multiome | 392 | |
| chr14:105,248,175–105,249,386 | 171.2 kb | Distal (>10kb) Multiome | 403 | |
| chr14:105,299,994–105,301,984 | 118.5 kb | Distal (>10kb) Multiome | 829 | |
| chr14:105,313,768–105,315,755 | 105.1 kb | Distal (>10kb) Multiome | 584 | |
| chr14:105,352,048–105,352,515 | 67.4 kb | Distal (>10kb) Multiome | 344 | |
| chr14:105,398,137–105,398,986 | 21.2 kb | Distal (>10kb) Multiome | 870 | |
| chr14:105,411,005–105,411,818 | 8.3 kb | Proximal (<10kb) Multiome | 384 | |
| chr14:105,414,595–105,414,761 | 5.0 kb | Proximal (<10kb) | 161 | |
| chr14:105,414,940–105,415,397 | 4.6 kb | Proximal (<10kb) Multiome | 447 | |
| chr14:105,419,281–105,420,109 | 113 bp | At TSS Multiome | 570 | |
| chr14:105,448,471–105,448,924 | 29.0 kb | Distal (>10kb) Multiome | 304 | |
| chr14:105,473,498–105,475,498 | 54.6 kb | Distal (>10kb) Multiome | 581 | |
| chr14:105,480,543–105,482,375 | 61.3 kb | Distal (>10kb) Multiome | 784 | |
| chr14:105,485,648–105,486,379 | 66.2 kb | Distal (>10kb) Multiome | 424 | |
| chr14:105,486,576–105,487,923 | 67.5 kb | Distal (>10kb) Multiome | 369 | |
| chr14:105,489,310–105,492,133 | 71.3 kb | Distal (>10kb) Multiome | 1014 | |
| chr14:105,526,110–105,527,233 | 106.8 kb | Distal (>10kb) Multiome | 270 | |
| chr14:105,528,085–105,528,965 | 108.8 kb | Distal (>10kb) Multiome | 568 |
Genomic view of the MTA1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.