Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MSS51. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSS51 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSS51, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,167,766–73,168,681 | 265.4 kb | Distal (>10kb) Multiome | 879 | |
| chr10:73,246,675–73,247,516 | 186.4 kb | Distal (>10kb) Multiome | 1023 | |
| chr10:73,252,167–73,253,067 | 180.9 kb | Distal (>10kb) Multiome | 929 | |
| chr10:73,358,383–73,358,977 | 74.8 kb | Distal (>10kb) Multiome | 468 | |
| chr10:73,413,302–73,414,453 | 19.5 kb | Distal (>10kb) Multiome | 938 | |
| chr10:73,495,235–73,496,398 | 62.4 kb | Distal (>10kb) Multiome | 908 | |
| chr10:73,591,236–73,591,781 | 157.9 kb | Distal (>10kb) Multiome | 359 | |
| chr10:73,591,961–73,592,227 | 158.5 kb | Distal (>10kb) Multiome | 458 | |
| chr10:73,625,111–73,626,369 | 192.4 kb | Distal (>10kb) Multiome | 810 | |
| chr10:73,647,157–73,648,042 | 214.0 kb | Distal (>10kb) Multiome | 238 | |
| chr10:73,730,165–73,730,854 | 297.0 kb | Distal (>10kb) Multiome | 823 |
Genomic view of the MSS51 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.