Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization and protein repair. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MSRB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSRB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSRB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:22,333,913–22,337,163 | 759.0 kb | Distal (>10kb) Multiome HiCAR | 477 | |
| chr10:22,810,644–22,811,385 | 284.7 kb | Distal (>10kb) Multiome | 202 | |
| chr10:22,897,054–22,897,738 | 198.1 kb | Distal (>10kb) Multiome | 105 | |
| chr10:22,927,465–22,928,426 | 167.6 kb | Distal (>10kb) Multiome | 411 | |
| chr10:23,095,104–23,096,550 | 42 bp | At TSS Multiome | 730 | |
| chr10:23,099,735–23,100,331 | 4.2 kb | Proximal (<10kb) | 159 | |
| chr10:23,191,250–23,193,411 | 96.7 kb | Distal (>10kb) Multiome | 360 | |
| chr10:23,198,669–23,200,168 | 103.6 kb | Distal (>10kb) Multiome | 266 | |
| chr10:23,343,359–23,344,847 | 248.6 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the MSRB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.