The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for MSRB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSRB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSRB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,677,899–1,679,024 | 265.0 kb | Distal (>10kb) Multiome | 709 | |
| chr16:1,705,380–1,706,702 | 237.1 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,763,511–1,764,353 | 179.2 kb | Distal (>10kb) Multiome | 261 | |
| chr16:1,770,847–1,771,973 | 171.6 kb | Distal (>10kb) Multiome | 485 | |
| chr16:1,772,565–1,774,049 | 169.8 kb | Distal (>10kb) Multiome | 956 | |
| chr16:1,781,749–1,783,420 | 160.4 kb | Distal (>10kb) Multiome | 761 | |
| chr16:1,826,102–1,827,535 | 116.3 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:1,918,171–1,918,773 | 24.7 kb | Distal (>10kb) Multiome | 129 | |
| chr16:1,929,283–1,930,271 | 13.4 kb | Distal (>10kb) Multiome | 780 | |
| chr16:1,942,671–1,943,761 | 175 bp | At TSS Multiome | 750 | |
| chr16:1,958,923–1,960,140 | 16.3 kb | Distal (>10kb) Multiome | 826 | |
| chr16:1,964,300–1,965,434 | 21.7 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,971,481–1,972,435 | 28.8 kb | Distal (>10kb) Multiome | 1010 | |
| chr16:1,979,111–1,980,324 | 36.2 kb | Distal (>10kb) Multiome | 296 | |
| chr16:1,983,450–1,984,851 | 40.8 kb | Distal (>10kb) Multiome | 917 | |
| chr16:1,989,307–1,993,568 | 49.2 kb | Distal (>10kb) Multiome | 706 | |
| chr16:2,003,882–2,004,348 | 60.8 kb | Distal (>10kb) Multiome | 619 | |
| chr16:2,009,742–2,010,504 | 66.7 kb | Distal (>10kb) Multiome | 752 | |
| chr16:2,022,700–2,023,923 | 80.1 kb | Distal (>10kb) Multiome | 682 | |
| chr16:2,026,629–2,027,149 | 83.7 kb | Distal (>10kb) Multiome | 249 | |
| chr16:2,047,366–2,048,252 | 104.7 kb | Distal (>10kb) Multiome | 875 | |
| chr16:2,090,476–2,092,232 | 148.1 kb | Distal (>10kb) Multiome | 344 | |
| chr16:2,135,536–2,136,505 | 192.9 kb | Distal (>10kb) Multiome | 263 | |
| chr16:2,147,864–2,149,260 | 205.3 kb | Distal (>10kb) Multiome | 679 | |
| chr16:2,149,550–2,152,180 | 207.9 kb | Distal (>10kb) Multiome | 618 | |
| chr16:2,152,861–2,153,999 | 210.5 kb | Distal (>10kb) Multiome | 734 | |
| chr16:2,154,834–2,156,329 | 212.4 kb | Distal (>10kb) Multiome | 932 | |
| chr16:2,178,140–2,179,722 | 235.6 kb | Distal (>10kb) Multiome | 318 | |
| chr16:2,205,129–2,206,297 | 262.3 kb | Distal (>10kb) Multiome | 887 | |
| chr16:2,214,212–2,215,803 | 271.8 kb | Distal (>10kb) Multiome | 953 | |
| chr16:2,223,095–2,224,285 | 280.3 kb | Distal (>10kb) Multiome | 918 |
Genomic view of the MSRB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.