Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPL38. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL38 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL38, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,633,694–75,634,328 | 271.0 kb | Distal (>10kb) Multiome | 559 | |
| chr17:75,666,763–75,667,767 | 237.8 kb | Distal (>10kb) Multiome | 783 | |
| chr17:75,720,933–75,721,693 | 183.8 kb | Distal (>10kb) Multiome | 509 | |
| chr17:75,753,534–75,754,285 | 151.2 kb | Distal (>10kb) Multiome | 699 | |
| chr17:75,764,621–75,765,674 | 139.9 kb | Distal (>10kb) Multiome | 769 | |
| chr17:75,778,786–75,780,191 | 125.2 kb | Distal (>10kb) Multiome | 1118 | |
| chr17:75,784,060–75,785,640 | 120.2 kb | Distal (>10kb) Multiome | 1176 | |
| chr17:75,827,420–75,828,293 | 77.3 kb | Distal (>10kb) Multiome | 404 | |
| chr17:75,830,158–75,830,695 | 74.7 kb | Distal (>10kb) Multiome | 190 | |
| chr17:75,832,912–75,833,396 | 71.9 kb | Distal (>10kb) Multiome | 104 | |
| chr17:75,845,103–75,845,662 | 59.7 kb | Distal (>10kb) Multiome | 703 | |
| chr17:75,854,955–75,856,363 | 49.6 kb | Distal (>10kb) Multiome | 1038 | |
| chr17:75,877,486–75,878,900 | 27.1 kb | Distal (>10kb) Multiome | 884 | |
| chr17:75,895,439–75,895,646 | 9.2 kb | Proximal (<10kb) | 256 | |
| chr17:75,896,392–75,897,754 | 8.1 kb | Proximal (<10kb) Multiome | 831 | |
| chr17:75,904,371–75,905,532 | 52 bp | At TSS Multiome | 1045 | |
| chr17:75,910,822–75,911,011 | 5.9 kb | Proximal (<10kb) | 16 | |
| chr17:75,940,734–75,941,471 | 36.0 kb | Distal (>10kb) Multiome | 982 | |
| chr17:75,978,646–75,980,102 | 74.3 kb | Distal (>10kb) Multiome | 1090 | |
| chr17:75,983,292–75,984,226 | 78.7 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,014,120–76,014,727 | 109.3 kb | Distal (>10kb) Multiome | 489 | |
| chr17:76,029,331–76,030,158 | 124.6 kb | Distal (>10kb) Multiome | 722 | |
| chr17:76,072,173–76,072,853 | 167.5 kb | Distal (>10kb) Multiome | 893 | |
| chr17:76,074,414–76,075,796 | 169.6 kb | Distal (>10kb) Multiome | 280 | |
| chr17:76,103,272–76,104,343 | 198.7 kb | Distal (>10kb) Multiome | 798 | |
| chr17:76,121,142–76,122,265 | 216.5 kb | Distal (>10kb) Multiome | 689 | |
| chr17:76,132,004–76,133,216 | 227.6 kb | Distal (>10kb) Multiome | 536 | |
| chr17:76,135,151–76,135,652 | 230.2 kb | Distal (>10kb) Multiome | 104 | |
| chr17:76,141,012–76,141,958 | 236.3 kb | Distal (>10kb) Multiome | 616 |
Genomic view of the MRPL38 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.