This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for MRI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:13,505,776–13,506,552 | 258.3 kb | Distal (>10kb) Multiome | 105 | |
| chr19:13,747,559–13,748,233 | 16.7 kb | Distal (>10kb) Multiome | 785 | |
| chr19:13,764,420–13,764,645 | at TSS | At TSS | 446 | |
| chr19:13,774,293–13,775,050 | 10.0 kb | Proximal (<10kb) Multiome | 904 | |
| chr19:13,794,728–13,795,999 | 30.7 kb | Distal (>10kb) Multiome | 763 | |
| chr19:13,817,290–13,818,525 | 53.5 kb | Distal (>10kb) Multiome | 368 | |
| chr19:13,833,328–13,834,074 | 69.2 kb | Distal (>10kb) Multiome | 638 | |
| chr19:13,841,592–13,843,282 | 78.4 kb | Distal (>10kb) Multiome | 600 | |
| chr19:13,846,368–13,848,126 | 83.2 kb | Distal (>10kb) Multiome | 1040 | |
| chr19:13,850,226–13,850,701 | 86.0 kb | Distal (>10kb) Multiome | 516 | |
| chr19:13,861,855–13,862,533 | 97.8 kb | Distal (>10kb) Multiome | 655 | |
| chr19:13,872,706–13,873,325 | 108.5 kb | Distal (>10kb) Multiome | 254 | |
| chr19:13,879,942–13,880,779 | 115.8 kb | Distal (>10kb) Multiome | 780 | |
| chr19:13,905,895–13,906,734 | 141.6 kb | Distal (>10kb) Multiome | 835 | |
| chr19:13,951,898–13,953,117 | 187.8 kb | Distal (>10kb) Multiome | 667 | |
| chr19:13,962,408–13,964,055 | 199.2 kb | Distal (>10kb) Multiome | 166 | |
| chr19:13,978,193–13,979,385 | 214.1 kb | Distal (>10kb) Multiome | 238 | |
| chr19:14,005,474–14,007,363 | 242.0 kb | Distal (>10kb) Multiome | 1098 | |
| chr19:14,031,574–14,032,483 | 267.6 kb | Distal (>10kb) Multiome | 726 | |
| chr19:14,057,383–14,057,841 | 293.2 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the MRI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.