Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleoplasm. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MRGBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRGBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRGBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:62,641,913–62,643,114 | 154.1 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr20:62,791,452–62,791,941 | 4.8 kb | Proximal (<10kb) Multiome | 645 | |
| chr20:62,793,003–62,795,717 | 2.1 kb | Proximal (<10kb) Multiome | 1051 | |
| chr20:62,795,820–62,796,113 | 358 bp | At TSS | 334 | |
| chr20:62,796,248–62,797,075 | 54 bp | At TSS Multiome | 566 | |
| chr20:62,804,667–62,805,076 | 8.2 kb | Proximal (<10kb) | 512 | |
| chr20:62,815,479–62,817,462 | 20.5 kb | Distal (>10kb) Multiome | 503 | |
| chr20:62,824,643–62,825,353 | 28.6 kb | Distal (>10kb) Multiome | 339 | |
| chr20:62,860,497–62,862,892 | 65.5 kb | Distal (>10kb) Multiome | 996 | |
| chr20:62,900,083–62,900,558 | 103.9 kb | Distal (>10kb) Multiome | 764 | |
| chr20:62,925,950–62,926,856 | 130.1 kb | Distal (>10kb) Multiome | 874 | |
| chr20:62,928,980–62,929,573 | 132.9 kb | Distal (>10kb) Multiome | 289 | |
| chr20:62,937,285–62,938,569 | 141.5 kb | Distal (>10kb) Multiome | 1026 | |
| chr20:63,006,367–63,007,246 | 210.5 kb | Distal (>10kb) Multiome | 189 | |
| chr20:63,071,594–63,072,696 | 275.5 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the MRGBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.