This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for MRAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:138,115,002–138,116,017 | 233.3 kb | Distal (>10kb) Multiome | 555 | |
| chr3:138,118,769–138,119,220 | 229.6 kb | Distal (>10kb) Multiome | 232 | |
| chr3:138,174,233–138,175,030 | 173.9 kb | Distal (>10kb) Multiome | 817 | |
| chr3:138,186,777–138,188,242 | 161.3 kb | Distal (>10kb) Multiome | 867 | |
| chr3:138,329,184–138,330,233 | 18.8 kb | Distal (>10kb) Multiome | 580 | |
| chr3:138,347,955–138,349,547 | 201 bp | At TSS Multiome | 615 | |
| chr3:138,417,585–138,418,044 | 69.1 kb | Distal (>10kb) Multiome | 243 | |
| chr3:138,434,084–138,435,298 | 85.9 kb | Distal (>10kb) Multiome | 811 | |
| chr3:138,608,484–138,609,385 | 260.3 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the MRAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.