This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MPV17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPV17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPV17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:27,032,577–27,033,271 | 290.2 kb | Distal (>10kb) Multiome | 799 | |
| chr2:27,049,564–27,052,299 | 272.3 kb | Distal (>10kb) Multiome | 1295 | |
| chr2:27,071,223–27,072,896 | 251.3 kb | Distal (>10kb) Multiome | 864 | |
| chr2:27,081,006–27,081,641 | 241.7 kb | Distal (>10kb) Multiome | 758 | |
| chr2:27,085,591–27,087,452 | 236.4 kb | Distal (>10kb) Multiome | 970 | |
| chr2:27,123,498–27,124,089 | 199.3 kb | Distal (>10kb) Multiome | 553 | |
| chr2:27,133,917–27,135,216 | 188.4 kb | Distal (>10kb) Multiome | 815 | |
| chr2:27,211,255–27,212,840 | 110.9 kb | Distal (>10kb) Multiome | 978 | |
| chr2:27,217,045–27,218,005 | 105.7 kb | Distal (>10kb) Multiome | 771 | |
| chr2:27,250,040–27,250,883 | 72.7 kb | Distal (>10kb) Multiome | 559 | |
| chr2:27,262,260–27,263,337 | 60.1 kb | Distal (>10kb) Multiome | 376 | |
| chr2:27,264,406–27,265,326 | 58.0 kb | Distal (>10kb) Multiome | 696 | |
| chr2:27,306,488–27,307,261 | 16.4 kb | Distal (>10kb) Multiome | 115 | |
| chr2:27,322,773–27,323,423 | 26 bp | At TSS Multiome | 906 | |
| chr2:27,356,094–27,357,596 | 33.9 kb | Distal (>10kb) Multiome HiCAR | 1084 | |
| chr2:27,369,685–27,371,261 | 47.3 kb | Distal (>10kb) Multiome | 1096 | |
| chr2:27,380,026–27,381,202 | 57.7 kb | Distal (>10kb) Multiome | 821 | |
| chr2:27,408,972–27,410,056 | 86.6 kb | Distal (>10kb) Multiome | 989 | |
| chr2:27,428,202–27,429,633 | 105.6 kb | Distal (>10kb) Multiome | 1013 | |
| chr2:27,441,811–27,442,884 | 119.3 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,489,334–27,490,205 | 166.8 kb | Distal (>10kb) Multiome | 731 | |
| chr2:27,494,797–27,495,577 | 172.1 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,517,085–27,517,958 | 194.5 kb | Distal (>10kb) Multiome | 130 | |
| chr2:27,582,572–27,583,317 | 259.9 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the MPV17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.