This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MPP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:43,545,066–43,547,010 | 287.5 kb | Distal (>10kb) Multiome | 999 | |
| chr17:43,694,216–43,694,699 | 138.7 kb | Distal (>10kb) Multiome | 408 | |
| chr17:43,720,542–43,721,150 | 112.3 kb | Distal (>10kb) Multiome | 572 | |
| chr17:43,755,308–43,755,795 | 77.7 kb | Distal (>10kb) Multiome | 248 | |
| chr17:43,760,231–43,760,686 | 72.7 kb | Distal (>10kb) Multiome | 539 | |
| chr17:43,778,079–43,779,460 | 54.3 kb | Distal (>10kb) Multiome | 937 | |
| chr17:43,832,658–43,833,385 | 22 bp | At TSS Multiome | 455 | |
| chr17:43,900,207–43,900,990 | 67.5 kb | Distal (>10kb) Multiome | 308 | |
| chr17:43,906,025–43,906,856 | 73.5 kb | Distal (>10kb) Multiome | 353 | |
| chr17:43,907,081–43,907,899 | 74.6 kb | Distal (>10kb) Multiome | 362 | |
| chr17:43,937,932–43,938,382 | 105.0 kb | Distal (>10kb) Multiome | 757 | |
| chr17:43,952,298–43,953,752 | 119.9 kb | Distal (>10kb) Multiome | 295 | |
| chr17:43,983,489–43,984,364 | 150.9 kb | Distal (>10kb) Multiome | 743 | |
| chr17:44,004,236–44,007,875 | 171.5 kb | Distal (>10kb) Multiome | 807 | |
| chr17:44,014,255–44,015,168 | 181.7 kb | Distal (>10kb) Multiome | 1020 | |
| chr17:44,066,017–44,066,857 | 233.4 kb | Distal (>10kb) Multiome | 722 | |
| chr17:44,070,107–44,071,340 | 237.6 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:44,095,480–44,096,263 | 262.8 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 278.1 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 290.6 kb | Distal (>10kb) Multiome | 883 |
Genomic view of the MPP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.