The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for MPDZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPDZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPDZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:13,278,160–13,280,119 | 157 bp | At TSS Multiome | 637 | |
| chr9:14,312,757–14,316,834 | 1036.1 kb | Distal (>10kb) Multiome HiCAR | 850 | |
| chr9:14,322,111–14,323,184 | 1043.2 kb | Distal (>10kb) Multiome HiCAR | 802 | |
| chr9:14,546,850–14,548,008 | 1268.0 kb | Distal (>10kb) Multiome HiCAR | 219 | |
| chr9:14,746,175–14,747,463 | 1467.7 kb | Distal (>10kb) Multiome HiCAR | 117 |
Genomic view of the MPDZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.