Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in protein secretion. Predicted to act upstream of or within establishment of localization in cell; intracellular iron ion homeostasis; and protein transport. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MON1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MON1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MON1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,718,116–49,720,106 | 210.2 kb | Distal (>10kb) Multiome | 450 | |
| chr3:49,723,361–49,724,517 | 205.8 kb | Distal (>10kb) Multiome | 769 | |
| chr3:49,785,831–49,787,202 | 143.3 kb | Distal (>10kb) Multiome | 854 | |
| chr3:49,802,203–49,804,006 | 127.0 kb | Distal (>10kb) Multiome | 733 | |
| chr3:49,856,099–49,857,163 | 73.2 kb | Distal (>10kb) Multiome | 664 | |
| chr3:49,869,590–49,870,249 | 60.1 kb | Distal (>10kb) Multiome | 251 | |
| chr3:49,903,411–49,904,277 | 25.9 kb | Distal (>10kb) Multiome | 415 | |
| chr3:49,929,290–49,930,212 | 92 bp | At TSS Multiome | 799 | |
| chr3:49,930,995–49,931,362 | 1.2 kb | Proximal (<10kb) | 150 | |
| chr3:49,939,635–49,940,747 | 10.2 kb | Distal (>10kb) Multiome | 949 | |
| chr3:50,088,748–50,089,596 | 159.0 kb | Distal (>10kb) Multiome | 677 | |
| chr3:50,121,279–50,122,037 | 191.8 kb | Distal (>10kb) Multiome | 364 | |
| chr3:50,154,437–50,155,741 | 225.1 kb | Distal (>10kb) Multiome | 450 | |
| chr3:50,204,913–50,205,545 | 275.3 kb | Distal (>10kb) Multiome | 367 | |
| chr3:50,205,645–50,206,357 | 276.3 kb | Distal (>10kb) Multiome | 347 | |
| chr3:50,226,120–50,228,328 | 296.4 kb | Distal (>10kb) Multiome | 915 |
Genomic view of the MON1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.