Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for MOCS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOCS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOCS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:50,730,245–50,732,382 | 227.6 kb | Distal (>10kb) Multiome | 1014 | |
| chr20:50,767,314–50,767,756 | 191.3 kb | Distal (>10kb) Multiome | 140 | |
| chr20:50,790,529–50,791,153 | 168.0 kb | Distal (>10kb) Multiome | 980 | |
| chr20:50,794,408–50,795,648 | 163.8 kb | Distal (>10kb) Multiome | 794 | |
| chr20:50,818,246–50,818,886 | 140.2 kb | Distal (>10kb) Multiome | 844 | |
| chr20:50,870,405–50,871,527 | 87.9 kb | Distal (>10kb) Multiome | 254 | |
| chr20:50,930,214–50,932,320 | 27.2 kb | Distal (>10kb) Multiome | 1082 | |
| chr20:50,958,262–50,959,227 | 142 bp | At TSS Multiome | 929 | |
| chr20:50,992,251–50,993,606 | 34.3 kb | Distal (>10kb) Multiome | 409 | |
| chr20:51,022,526–51,023,913 | 64.4 kb | Distal (>10kb) Multiome | 437 | |
| chr20:51,091,663–51,092,800 | 133.2 kb | Distal (>10kb) Multiome | 122 | |
| chr20:51,221,628–51,222,684 | 263.3 kb | Distal (>10kb) Multiome | 366 | |
| chr20:51,373,737–51,374,717 | 415.4 kb | Distal (>10kb) Multiome HiCAR | 259 | |
| chr20:51,542,047–51,542,945 | 583.9 kb | Distal (>10kb) Multiome HiCAR | 490 |
Genomic view of the MOCS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.