Predicted to be a structural constituent of myelin sheath. Predicted to be involved in nervous system development. Predicted to be located in mitochondrion and perinuclear region of cytoplasm. Implicated in frontotemporal dementia. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MOBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:39,177,458–39,178,406 | 289.7 kb | Distal (>10kb) Multiome | 531 | |
| chr3:39,180,469–39,181,324 | 286.7 kb | Distal (>10kb) Multiome | 541 | |
| chr3:39,288,216–39,288,885 | 179.2 kb | Distal (>10kb) Multiome | 463 | |
| chr3:39,406,328–39,407,246 | 61.0 kb | Distal (>10kb) Multiome | 1019 | |
| chr3:39,505,565–39,507,064 | 38.6 kb | Distal (>10kb) Multiome | 225 | |
| chr3:39,577,488–39,578,453 | 110.1 kb | Distal (>10kb) Multiome | 139 | |
| chr3:39,665,431–39,666,067 | 197.9 kb | Distal (>10kb) Multiome | 44 |
Genomic view of the MOBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.