Transcription factors with Perturb-seq knockdown data for MNX1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MNX1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MNX1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:157,003,166–157,003,532 | 7.3 kb | Proximal (<10kb) | 120 | |
| chr7:157,003,648–157,004,372 | 6.4 kb | Proximal (<10kb) | 255 | |
| chr7:157,009,113–157,012,019 | at TSS | At TSS | 793 | |
| chr7:157,013,630–157,014,425 | 2.8 kb | Proximal (<10kb) | 180 | |
| chr7:157,017,564–157,018,575 | 6.8 kb | Proximal (<10kb) | 123 | |
| chr7:157,018,926–157,019,665 | 8.1 kb | Proximal (<10kb) | 143 | |
| chr7:157,020,746–157,021,949 | 9.9 kb | Proximal (<10kb) | 146 |
Genomic view of the MNX1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.