This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for MMP17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMP17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMP17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:131,623,903–131,626,152 | 203.1 kb | Distal (>10kb) Multiome | 286 | |
| chr12:131,682,187–131,682,744 | 146.0 kb | Distal (>10kb) Multiome | 150 | |
| chr12:131,710,558–131,711,365 | 117.5 kb | Distal (>10kb) Multiome | 947 | |
| chr12:131,827,942–131,828,736 | 2 bp | At TSS Multiome | 309 | |
| chr12:131,829,212–131,829,595 | 820 bp | At TSS | 228 | |
| chr12:131,830,019–131,831,053 | 2.2 kb | Proximal (<10kb) Multiome | 495 | |
| chr12:131,894,077–131,895,155 | 66.1 kb | Distal (>10kb) Multiome | 460 | |
| chr12:131,895,483–131,896,833 | 67.8 kb | Distal (>10kb) Multiome | 784 | |
| chr12:131,928,499–131,930,478 | 100.7 kb | Distal (>10kb) Multiome | 908 | |
| chr12:131,949,435–131,950,660 | 121.5 kb | Distal (>10kb) Multiome | 770 | |
| chr12:132,083,735–132,085,216 | 255.8 kb | Distal (>10kb) Multiome | 882 |
Genomic view of the MMP17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.