This gene encodes a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for MMD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:4,681,869–4,682,504 | 277.0 kb | Distal (>10kb) Multiome | 517 | |
| chr7:4,707,922–4,708,359 | 251.0 kb | Distal (>10kb) Multiome | 107 | |
| chr7:4,744,414–4,745,493 | 214.0 kb | Distal (>10kb) Multiome | 673 | |
| chr7:4,775,021–4,775,903 | 183.7 kb | Distal (>10kb) Multiome | 860 | |
| chr7:4,791,775–4,793,216 | 166.8 kb | Distal (>10kb) Multiome | 359 | |
| chr7:4,798,157–4,798,757 | 160.9 kb | Distal (>10kb) Multiome | 349 | |
| chr7:4,882,152–4,884,513 | 75.5 kb | Distal (>10kb) Multiome | 585 | |
| chr7:4,973,785–4,974,732 | 14.8 kb | Distal (>10kb) Multiome | 674 | |
| chr7:5,045,501–5,046,448 | 86.6 kb | Distal (>10kb) Multiome | 594 | |
| chr7:5,189,698–5,190,896 | 231.0 kb | Distal (>10kb) Multiome | 725 | |
| chr7:5,240,214–5,240,895 | 281.2 kb | Distal (>10kb) Multiome | 613 |
Genomic view of the MMD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.