Transcription factors with Perturb-seq knockdown data for MMADHC-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMADHC-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMADHC-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:149,037,769–149,039,431 | 548.6 kb | Distal (>10kb) Multiome HiCAR | 414 | |
| chr2:149,329,167–149,331,592 | 256.9 kb | Distal (>10kb) Multiome | 688 | |
| chr2:149,587,059–149,588,359 | 362 bp | At TSS Multiome | 991 | |
| chr2:150,484,918–150,488,116 | 900.3 kb | Distal (>10kb) Multiome HiCAR | 788 | |
| chr2:150,675,594–150,676,590 | 1088.6 kb | Distal (>10kb) Multiome HiCAR | 114 | |
| chr2:151,261,080–151,262,216 | 1674.3 kb | Distal (>10kb) Multiome HiCAR | 869 | |
| chr2:151,408,735–151,410,773 | 1822.5 kb | Distal (>10kb) Multiome HiCAR | 1137 |
Genomic view of the MMADHC-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.